. 2011 Aug 17;6(8):e23473. doi: 10.1371/journal.pone.0023473

Table 1. Associations with sufficient power for detection (> = 80%) that failed to replicate.

Phenotype	SNP	Pub OR	Rep OR	P-value	Power	Cases	Controls	Replications in the Literature
Alcohol abuse	rs7590720	1.35	0.955	0.875	1	1811	8549	Failed to replicate [30]
Bipolar disorder	rs1012053	1.59	1	0.485	1	366	13030	Failed to replicate [31]–[34]
Bipolar disorder	rs420259	2.08	0.966	0.659	1	366	13030	Failed to replicate [32]–[34]
COPD^a	rs13180	1.3	1.05	0.26	0.89	403	2306	Replicated [35]
COPD^a	rs7671167	1.32	1.11	0.0968	0.93	403	2306	Replicated [35]
COPD^a	rs1828591	1.38	1	0.489	0.97	403	2306	Replicated [36], [37]
Crohn's disease	rs2066847	3.99	1.54	0.151	0.88	84	13288	Replicated [38]
IBD^b	rs7517847	1.61	0.855	0.954	1	250	12808	Replicated [39] ^c
Juvenile allergic asthma	rs2786098	1.43	1.07	0.181	1	641	6584	Failed to replicate [40]
Lupus	rs3131379	2.36	1.38	0.133	0.82	52	11675	Not yet replicated
Parkinson's disease	rs17115100	1.25	0.992	0.555	0.97	2274	5336	Not claimed [41] ^d
Parkinson's disease	rs823128	1.52	1.17	0.0531	1	2274	5336	Not claimed [41] ^d
Psoriasis	rs20541	1.27	1.09	0.0953	0.92	833	4291	Replicated [42], [43]
Rheumatoid arthritis	rs10499194	1.33	0.927	0.797	0.9	308	12845	Failed to replicate [44]
Rheumatoid arthritis	rs3761847	1.32	1.01	0.437	0.93	308	12845	Between-study heterogeneity [45]
Type 2 diabetes	rs9300039	1.48	0.976	0.595	0.97	778	3273	Between-study heterogeneity [46]
Type 2 diabetes	rs2943641	1.19	1.03	0.328	0.81	778	3273	Not yet replicated
Thyroid cancer	rs965513	1.75	1.37	0.0559	0.83	52	11234	Replicated [47]
Ulcerative colitis	rs11209026	1.79	1.47	0.0577	0.85	181	13100	Replicated [48]

Pub OR = published odds ratio. Rep OR = 23andMe attempted replication odds ratio. Power = estimated power to detect association.

COPD = Chronic Obstructive Pulmonary Disease. This analysis included smokers only.

IBD = Inflammatory Bowel Disease.

This SNP was initially associated with IBD, but replicated only for Crohn's disease [39], which is a subtype of IBD. Latiano et al. also replicates rs7517847 with Crohn's disease, but not with ulcerative colitis, which is the other major subtype of IBD [14].

This association was curated into the GWAS catalog as significantly associated with Parkinson's disease but was not identified by the authors as significant.