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. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: Dev Cell. 2011 Aug 4;21(2):315–327. doi: 10.1016/j.devcel.2011.06.028

Figure 7. Unsumoylatable SF-1 prevails over the wild type SF-1 and ectopically activates SUMO-sensitive genes in vivo.

Figure 7

A. Shh and Sox9 transcripts levels are shown for E16.5 testes and adult male adrenals, respectively. Statistical significance was determined by one-way ANOVA. B. Comparison of adult adrenals obtained from different allelic combinations as indicated, by either tyrosine hydroxylase staining of adrenal medulla (green), or AKR1C18/20α-HSD staining, which marks cells of the fetal X-zone (brown, black arrows). The eccentric smaller medulla observed in heterozygous Sf-1+/− adrenal is further exaggerated in Sf-12KR/− adrenals.