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. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: Dev Cell. 2011 Aug 4;21(2):315–327. doi: 10.1016/j.devcel.2011.06.028

Figure 8. Sumoylation of SF-1 is critical for normal endocrine tissue development.

Figure 8

A schematic summarizing our results showing that shifting the normal ratio of sumoylated to unsumoylated SF-1 to only unmodified SF-1 (left bottom panel) in Sf-12KR/2KR mice interferes with normal endocrine tissue development and results in the ectopic expression of SUMO-sensitive SF-1 target genes, such as Shh (dark blue), Sox9 (red), and Akr1c18, which marks the fetal X-zone (brown ring in adrenal). We hypothesize that the correct ratio of sumoylated to unmodified substrate is needed to selectively turn on/off developmental gene programs (right panel). Transcriptional co-activators (CoA) and/or co-repressors (CoR) might also be involved in this process.