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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Biomed Mater Res A. 2011 Jun 28;98(3):323–331. doi: 10.1002/jbm.a.33154

Figure 4.

Figure 4

Gene expression profiles of bone-specific markers of osteoblastic differentiation alkaline phosphatase (ALP), osteocalcin (OC) and osteopontin (OP) as determined by RT-PCR. The data demonstrate significantly increased expression in mesenchymal stem cells cultured on titanium fiber meshes with ex vivo generated ECM (blue line) compared to those cells cultured on control titanium fiber meshes without ECM (black line). A * symbol indicates a significant difference in expression level at the specified timepoint (p <0.05); a # symbol indicates a significant difference in expression level with respect to the baseline (p <0.05); a + symbol indicates a significant increase in expression level from the previous timepoint. The dashed grey line indicates the baseline expression level. Reprinted in part and with permission from [111].