Table 3.
Studies of The Effect of Cardiovascular Disease Outcomes on Mortality
| Mortality | |||
|---|---|---|---|
| Cohort Studies | Year | Clinical variables/outcomes | NOS |
| Gelfand et al.82 | 2007 | There was no overall effect of mild psoriasis on mortality, whereas patients with severe psoriasis demonstrated increased overall mortality risk. The association of severe psoriasis with mortality persisted after adjustment for risk factors for mortality and after exclusion of patients with inflammatory arthropathy. Male and female patients with severe psoriasis died 3.5 and 4.4 years younger than patients without psoriasis | 7 of 9 |
| Mallbris et al.83 | 2004 | Using the Swedish Inpatient Registry, there appeared to be no increased cardiovascular mortality among outpatients with psoriasis. Overall risk among inpatients admitted at least once was increased by 50%. Cardiovascular mortality was higher among those admitted at younger ages, specifically for patients aged 20 to 39 years at first admission | 7 of 9 |
| Shbeeb et al.93 | 2000 | Based upon a cohort of patients drawn from community database with psoriatic arthritis, survival was not significantly different from the general population. However, their analysis may exclude patients with severe arthritis who were seen in the hospital setting | 5 of 9 |
| Stern et al.81 | 1988 | Using the Psoralen and UV-A follow-up study, the incidence of death and causes of death were comparable to those expected in the general population. There was no increase in cardiovascular mortality observed, but they found that cirrhosis caused more deaths among their cohort than in the general population) | 7 of 9 |
| Wong et al.84 | 1997 | The 4 leading causes of death observed in patients with PsA were diseases of the circulatory or respiratory systems, malignant neoplasms, , and injuries/poisoning. Specifically, 27.6% of patients died from MIs, 4.3% from CVAs, and 4.3% from congestive heart failure and arteriosclerosis. The SMR for the female cohort was 1.59 and the men 1.65. However, deaths from circulatory diseases did not appear to differ significantly from those expected in the general population | 7 of 9 |
| Also see: Poikolainen (Alcohol Consumption, 74) | |||
| Cross-sectional Studies | Year | Clinical variables/outcomes | CSQ |
| Gladman et al. 94 | 1998 | Patients with psoriatic arthritis had an increased risk of death, after adjustment for age and sex, compared with the general population of Ontario. The combined standardized mortality ratio (SMR) for both men and women was estimated to be 1.62, with an associated confidence interval of 1.21-2.12. For women, the SMR was 1.59, and for men, it was 1.65, indicating a 59% and 66% increase in the death rate among female and male patients with PsA, respectively. | 5 of 11 |
| Prodanovich et al.79 | 2009 | After controlling for risk factors, patients with psoriasis had a higher prevalence of ischemic heart disease, cerebrovascular, and peripheral vascular disease . Psoriasis was also found to be an independent risk factor for mortality | 9 of 11 |
| Abbreviations: CSQ, Cross-sectional Study Quality; NOS, Newcastle–Ottawa Score | |||