Table 4.
Effect of eQTL transcripts (A) and eSNPs (B) on cardiovascular risk factors and phenotypes of subclinical atherosclerotic disease. Table shows the strength of association by beta estimates or odds ratios with the corresponding 95% confidence interval and uncorrected P-values. An asterisk marks P-values that remain significant after correction for FDR.
| A. | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Transcript | Probe ID | LDL Cholesterol (mg/dL) |
HDL Cholesterol (mg/dL) |
Log Triglycerides (mg/dL) |
Diabetes mellitus (%) |
Log HbA1c (%) |
Systolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Carotid Macroangiopathy (Yes/No) |
Flow-mediated vasodilation (%) |
|
Strength of association (Beta Estimate for continuous traits or OR for dichotomous traits with 95% CI, P-value)
|
||||||||||
| LIPA | ILMN_1718063 | 4.58 [-0.58 - 9.74] 0.082 |
-3.51 [-5.78 - -1.23] 2.5*10-3* |
0.06 [-0.01 - 0.13] 0.0836 |
0.84 [0.49 - 1.44] 0.533 |
0.01 [-0.01 - 0.03] 0.148 |
-2.71 [-5.25 - -0.17] 3.9*10-2 |
0.003 [-1.39 - 1.40] 0.997 |
0.94 [0.60 - 1.46] 0.782 |
-1.06 [-1.79 - -0.34] 4.04*10-3* |
| PSRC1 | ILMN_1671843 | -12.02 [-20.94 - -3.11] 8.2*10-3* |
6.00 [2.041 - 9.95] 3.0*10-3* |
-0.14 [-0.26 - -0.02] 2.8*10-2 |
0.61 [0.24 - 1.56] 0.303 |
-0.01 [-0.04 - 0.02] 0.524 |
-8.76 [-13.17 - -4.36] 9.96*10-5* |
-4.43 [-6.85 - -2.00] 3.5*10-4* |
0.35 [0.16 - 0.76] 8.05*10-3* |
2.39 [1.12 - 3.65] 2.2*10-4* |
| PSRC1 | ILMN_2315964 | -1.95 [-5.01 - 1.12 0.213 |
0.27 [-1.09 - 1.63] 0.701 |
-0.01 [-0.05 - 0.03] 0.591 |
1.10 [0.8 - 1.57 0.574 |
-0.01 [-0.02-0.01 0.370 |
-1.65 [-3.17- -0.12] 3.4*10-2 |
-0.75 [-1.59- 0.09 0.080 |
0.89 [0.702-1.167 0.398 |
0.36 [-0.08- 0.79 0.105 |
| FAM117B | ILMN_1739942 | 7.70 [0.97 - 14.44] 2.5*10-2 |
0.67 [-2.3 - 3.64] 0.658 |
0.07 [-0.02 - 0.16] 0.136 |
1.28 [0.63 - 2.66] 0.506 |
-0.007 [-0.03 - 0.02] 0.538 |
1.13 [-2.18 - 4.45] 0.503 |
0.27 [-1.55 - 2.09] 0.771 |
1.35 [0.76 - 2.44] 0.322 |
0.02 [-0.93 - 0.98] 0.962 |
| B. | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Gene | Risk/ NonRisk Allele |
LDL Cholesterol (mg/dL) |
HDL Cholesterol (mg/dL) |
Log Trigylcerides (mg/dL) |
Diabetes mellitus (%) |
Log HbA1c (%) |
Systolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Carotid Microangiopathy (Yes/No) |
Flow-mediated vasodilation (%) |
|
Strength of association (Beta Estimate with 95% CI, P Value)
|
||||||||||||
| rs1412444 | 10 | LIPA | T / C | 1.11 (-0.8 - 3.02) 0.25 |
-0.68 (-1.55 - 0.18) 0.12 |
0.01 (-0.01 - 0.04) 0.37 |
0.88 (0.71 - 1.1) 0.28 |
0 (-0.01 - 0.01) 0.94 |
0.16 (-0.8 - 1.11) 0.75 |
-0.1 (-0.62 - 0.41) 0.70 |
1.06 (0.89 - 1.25) 0.51 |
0 (-0.27 - 0.27) 0.98 |
| rs2246833 | 10 | LIPA | T / C | 1.25 (-0.65 - 3.14) 0.20 |
-0.76 (-1.62 - 0.1) 0.084 |
0.02 (-0.01 - 0.04) 0.25 |
0.9 (0.73 - 1.12) 0.35 |
0 (-0.01 - 0.01) 0.99 |
0.17 (-0.78 - 1.11) 0.73 |
-0.17 (-0.68 - 0.35) 0.52 |
1.06 (0.89 - 1.25) 0.52 |
-0.02 (-0.29 - 0.25) 0.88 |
| rs629301 () | 1 | CELSR2 | T / G | 3.93 (1.83 - 6.04) 2.0*10-4* |
-0.05 (-1.01 - 0.9) 0.91 |
0 (-0.03 - 0.03) 0.96 |
1.07 (0.84 - 1.36) 0.59 |
0 (0 - 0.01) 0.35 |
0.37 (-0.68 - 1.43) 0.49 |
-0.28 (-0.85 - 0.29) 0.34 |
1.43 (1.16 - 1.76) 1.0*10-3* |
0.12 (-0.18 - 0.42) 0.44 |
| rs599839 () | 1 | PSRC1 | A / G | 3.96 (1.87 -6.06) 2.0*10-4* |
0.06 (-0.89 - 1.01) 0.90 |
0 (-0.03 - 0.03) 0.92 |
1.1 (0.86 - 1.4) 0.45 |
0 (0 - 0.01) 0.36 |
0.39 (-0.66 - 1.44) 0.47 |
-0.18 (-0.75 - 0.38) 0.53 |
1.44 (1.17 - 1.76) 1.0*10-3* |
0.07 (-0.23 - 0.36) 0.66 |
| rs6725887 () | 2 | WDR12 | C / T | -1.76 (-4.38 - 0.86) 0.20 |
0.13 (-1.07 - 1.32) 0.84 |
-0.04 (-0.07 - 0) 0.042 |
0.97 (0.72 - 1.3) 0.82 |
0 (-0.01 - 0.01) 0.87 |
-0.33 (-1.65 - 0.98) 0.62 |
-0.58 (-1.3 - 0.13) 0.11 |
0.77 (0.6 - 0.99) 4.2*10-2 |
0.4 (0.02 - 0.77) 3.7*10-2 |