Table 2.

Variable estimates from the final pentobarbital population pharmacokinetic model.

Variable	Estimate	SE%
CL (L/hr)	0.52	8.4
V1(L)	3.10	7.6
Q (L/hr)	9.64	5.2
V2 (L)	6.75	4.8
Age effect CL	0.23	50.0
TBYP effect CL	0.0039	4641.0
TBYP effect V1	−0.04	404.5
Single-Ventricle effect CL	0.85	8.1
Variable	Inter-Individual Variability	SE%
ω2Cl	42.3	41.7
ω2V1	41.5	31.5
ω2V2	32.7	46.1
Variable	Covariance	SE%
CovCL, V1	0.01	367.6
CovCL, V2	0.04	98.6
CovV1, V2	0.01	363.4
Residual Variability	Variance	SE%
σ2proportional	0.01	100

SE% = (standard error/parameter estimate) *100

Inter-individual variability = (square-root of variance) *100

For age less than 12 months:

CL = θ_CL* (WT/6.9)^0.75*(AGE/5.2)^0.23* (TBYP/60)^0.0039* [0.85(for single-ventricle only)]

For age greater than 12 months:

CL = θ_CL* (WT/6.9)^0.75* (TBYP/60)^0.0039* [0.85(for single-ventricle only)]

For all ages:

V1 = θ_V1 * (WT/6.9)¹* (TBYP/60)^−0.04

Q = θ_Q* (WT/6.9)^0.75

V2 = θ_V2* (WT/6.9)¹