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. 2011 Aug 1;51(3-3):763–772. doi: 10.1016/j.freeradbiomed.2011.05.027

Fig. 2.

Fig. 2

The effects of in vivo treatment with GW1929 on ROS production by wild-type mouse lungs. (A) Lucigenin chemiluminescence using lung homogenates. Left: kinetic measurement of O2•− production. Right: the effect of Cu/Zn-SOD inhibitor, DDC, on the levels of NADPH-dependent O2•− production. *P < 0.05 for indicated values versus vehicle values. (B) The effects of various enzyme inhibitors on the levels of NADPH-dependent O2•− production measured by lucigenin chemiluminescence. *P < 0.05 for indicated values versus GW1929 values. (C) Left: representative images of DHE fluorescence in lung sections. Right: quantification of DHE fluorescence. *P < 0.05 for indicated values versus vehicle values under the same conditions. Scale bar = 50 μm.