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Reduced expression of TLR-2, -3, -4 and -7 following exposure of mouse splenocytes to 0.1 mM of CRN as determined by immunofluorescent staining. Immunohistochemical staining of cytospins prepared from splenocytes treated with CRN demonstrates that CRN results downregulates TLR-2, TLR-3, TLR-4, and TLR-7 relative to the levels observed in the control-treated cells.
