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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Hear Res. 2011 Mar 21;279(1-2):67–73. doi: 10.1016/j.heares.2011.03.007

Figure 1.

Figure 1

Auditory nerve inputs that synapse onto fusiform cells do not show short- or long-term endocannabinoid-mediated synaptic plasticity. (A) Simplified circuitry of dorsal cochlear nucleus (DCN). (B) Depolarization to 10mV of fusiform cells for 1s fails to induce DSE in auditory nerve inputs (average DSE 3 s after depolarization: 0.7% ± 9.8%; n=6). Traces represent EPSCs taken 1–3 s before and after depolarization. (C1-3) Pairing of spikes and EPSCs fail to induce STDP in auditory nerve inputs. (C1) STDP induction protocol composed of 5 pairs, at 100ms interval, repeated 10 times at 0.2 Hz. (C2) Representative traces of EPSPs before and 15–20 min after the pairing protocol. (C3) Average time course of auditory nerve EPSPs before and after pairing (97% ± 8%, 15–20 min after pairing, n = 5); Arrow indicates when the STDP induction protocol was applied.