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. Author manuscript; available in PMC: 2012 Aug 24.
Published in final edited form as: J Am Chem Soc. 2011 Jul 29;133(33):13176–13182. doi: 10.1021/ja204980v

Scheme 1.

Scheme 1

NF-κB regulated transcription in the presence of DNA decoys. A) Upon stimulation, NF-κB translocates into the nucleus and binds to its DNA binding site activating transcription. B) In the presence of DNA decoys, NF-κB binds to the DNA decoy over its genomic binding site, leading to an inhibition of transcription.