Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Photochemical control over NF-κB activation of gene expression. The caging groups disrupt Watson-Crick base-pairing of DNA and thus hairpin formation, rendering the decoy inactive. Therefore, NF-κB binds to its native genomic binding site and initiates transcription. After a brief irradiation with UV light, the caging groups are removed, the hairpin decoy forms, and out-competes the natural NF-κB binding site, leading to the inhibition of gene expression.
