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. Author manuscript; available in PMC: 2011 Aug 18.
Published in final edited form as: Curr Alzheimer Res. 2011 Jun 1;8(4):366–372. doi: 10.2174/156720511795745375

Table 1.

PiB retention values in older adults without cognitive impairment, with mild cognitive impairment, and those with Alzheimer’s disease

Author Year Design Sample #Subjects Mean Age Method PiB in AD PiB in MCI PiB in CN Findings
Rowe 2007 Case control AD, DLB, FTD, MCI, CN 17 AD, 10 DLB, 6 FTD, 9 MCI, 27CN 74 AD, 72 DLB, 71.5 FTD, 73 MCI, 72 CN DVR0–90r

  • Mean=2

  • Frontal=2.02–2.19

  • LatTemp=1.9

  • PCG=2.19

  • Parietal=1.93

  • Mean=1.6

  • Frontal=1.45–1.71

  • Parietal=1.49

  • LatTemp=1.5

  • PCG=1.72

  • Mean=1.2

  • Frontal=1.12–1.30

  • Parietal=1.1

  • PCG=1.27

  • LatTemp=1.19

  • Global / Regional: AD > CN (p>0.05)

  • Global / Regional: MCI > CN (p>0.05)
Li 2008 Case control AD, MCI, CN 17 AD, 13 MCI, 7 CN 72 AD, 72 MCI, 69 CN DVR0–90r

  • MFG=1.92

  • STG=1.67

  • IP=1.82

  • PCG=1.93

  • MFG=1.5

  • STG=1.36

  • IP=1.48

  • PCG=1.58

  • MFG=1.16

  • IP=1.19

  • STG=1.15

  • PCG=1.26

  • Regional: AD > CN (p>0.05)

  • Regional: AD > MCI (p>0.05)
Price 2005 Case control AD, MCI, CN 5 AD, 5MCI, 5 CN 68 AD, 71MCI, 59CN DVR35–90r, also SUVR40–60r,)

  • Frontal=2.63,

  • Parietal=2.55,

  • PCG=2.63,

  • LatTemp=2.37

  • Frontal=1.81,

  • Parietal=1.87,

  • PCG=1.93,

  • LatTemp=1.79

  • Frontal=1.32,

  • Parietal=1.29,

  • PCG=1.24,

  • LatTemp=1.19

  • Regional: AD > CN (p>0.05)
Mintun 2006 Case control AD, nondeme nted 10 AD (CDR>0), 41 CDR=0 (20 older CN mean age 77) 77AD, 65CN BP0–60r

  • Mean=0.633

  • Mean=0.098

  • Global: AD > CN (p < 0.0001)
Klunk 2004 Case control AD, CN 16 mild AD, 9 CN 65 AD, 69 older CN, 21 young CN SUVR40–60r

  • Frontal=1.56

  • Parietal=1.45

  • LatTemp=1.26

  • Frontal=0.8

  • Parietal=0.85

  • LatTemp=0.83

  • Regional: AD > CN (p < 0.006)
Forsberg 2008 Case control MCI, AD, CN 21 MCI, 27 AD, 6 CN 63.3 MCI, 66 AD, 67 CN SUVR40–60r

  • Frontal = 2.3

  • Parietal=2.2

  • Temporal=1.8

  • PCG=2.2

  • Frontal=1.6

  • Parietal=1.7

  • PCG=1.7

  • Temporal=1.5

  • Frontal=1.3

  • Parietal=1.3

  • PCG=1.4

  • Temporal=1.3

  • Regional: MCI converters > CN (p<0.01)

  • Regional: AD > MCI and MCI nonconverters (p<0.01)
Pike 2007 Case control AD, MCI, CN 31 AD, 33 MCI, 32 CN 75 AD, 71MCI, 72CN SUVR40–70r

  • Mean =2.42

  • Mean= 1.85

  • Mean=1.4

  • Global: MCI > CN (p<0.001)

  • Global: AD > MCI (p<0.001)
Kemppai nen 2006 Case control AD, CN 17 AD, 11 CN 72 AD, 65 CN SUVR60–90r

  • Frontal = 1.73

  • Parietal=1.49

  • PCG=1.81

  • Temporal=1.52

  • Frontal=1.06

  • Parietal=1.02

  • PCG=1.24

  • Temporal = 1.05

  • Regional: AD > CN (p<0.001)
Kemppai nen 2007 Case control Amnestic MCI (aMCI), CN 13 aMCI, 14 CN 70 aMCI, 65 CN SUVR60–90rv

  • Frontal = 1.5

  • Parietal=1.49

  • PCG=1.92

  • LatTemp=1.59

  • Frontal=1.08

  • Parietal=1.14

  • PCG=1.38

  • LatTemp 1.24

  • Regional: MCI > CN (p<0.01)
Edison 2007 Case control AD, CN 19 AD, 14 CN 66 AD, 64 CN SUVR60–90rv

  • Primary motor cortex = 1.7

  • Primary sensory cortex = 1.76

  • Primary visual cortex=1.63

  • Primary motor cortex=1.26

  • Primary sensory cortex =1.21

  • Primary visual cortex = 1.63

  • Regional: AD > CN (p<0.001)

PiB: [11C] Pittsburgh compound-B. AD: Alzheimer’s disease. DLB: Dementia with Lewy bodies. FTD: Frontotemporal Dementia. MCI: Mild Cognitive Impairment. CN: Cognitively Normal. DVR0–90r: Distribution Volume Ratio quantified over 90 minutes; ROI analysis. DVR35–90r : Distribution Volume Ratio determined using data from 35–90 minutes; ROI analysis. BP0–60r: Binding Potential quantified over 60 minutes; ROI analysis. SUV40–60r Standardized Uptake Value Ratio, quantified from 40 to 60 minutes; ROI analysis. SUV60–90rv: Standardized Uptake Value Ratio, quantified from 60 to 90 minutes; ROI and voxel based analysis. Mean: Mean cortical PiB retention (average of frontal, parietal, lateral temporal and in some studies occipital regions). LatTemp: Lateral temporal cortex. PCG: Posterior cingulate gyrus. MFG: Middle frontal gyrus. STG: Superior temporal gyrus. IP: inferior parietal lobe. Age was not rounded up.