Table 1.
Mutations Covered in the Solid Tumor Panel
| Gene | No. of annotated mutant solid tumor cases in COSMIC | Percentage of COSMIC solid tumor cases covered in Solid Tumor Panel⁎ |
|---|---|---|
| ABL1 | 5 | 0% |
| AKT1 | 115 | 95% |
| AKT2 | 0 | NA |
| AKT3 | 2 | 0% |
| BRAF | 12870 | 98% |
| CDK4 | 0 | NA |
| CTNNB1 | 2667 | 76% |
| EGFR | 5292 | 80% |
| ERBB2 | 116 | 33% |
| FBX4 | 0 | NA |
| FBXW7 | 146 | 31% |
| FGFR1 | 10 | 20% |
| FGFR2 | 62 | 27% |
| FGFR3 | 2012 | 28% |
| FLT3 | 2 | 0% |
| GNAQ | 139 | 96% |
| HRAS | 626 | 91% |
| JAK2 | 5 | 0% |
| KIT | 2601 | 48% |
| KRAS | 14235 | 99% |
| MAP2K1 | 0 | NA |
| MAP2K2 | 0 | NA |
| MET | 140 | 51% |
| NRAS | 1353 | 98% |
| PDGFRA | 540 | 72% |
| PIK3CA | 2772 | 89% |
| PTPN11 | 15 | 7% |
| RET | 369 | 78% |
| SOS1 | 2 | 0% |
| TP53 | 11584 | 21% |
COSMIC, Catalogue of Somatic Mutations in Cancer (http://www.sanger.ac.uk/genetics/CGP/cosmic).
NA, not available.
⁎
Proportion of solid tumor cases in COSMIC with a mutation that would be detected by the Solid Tumor Panel.