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. 2011 Jun 13;26(9):2473–2485. doi: 10.1093/humrep/der183

Figure 1.

Figure 1

Weight and metabolic characterization of mouse cohorts. The average weights of (A) different aged mice (D49, D100, D270 and D100*) and (B) D49 mice in different stages of the estrous cycle (estrus, metestrus and diestrus) are shown. To examine the independent effect of animal weight on in vitro follicle growth, a 100 day-old mouse cohort that was similar in weight to D270 mice was generated (D100*) through diet modification. Differences in weight between D49 and D100 compared with D270 and D100* were statistically significant (P<0.001). Differences in weight between mice in estrus and metestrus compared with those in diestrus were also statistically significant (P<0.05). (C) Total serum cholesterol was measured in D49, D100, D270 and D100* mice, and levels in D270 and D100* mice were statistically higher than in D100 mice (P<0.05). (D) IPGTT analysis was performed on D100, D270 and D100* mice following a 6 h fast and blood glucose levels are shown for 2 h post-glucose challenge. (E) Blood glucose levels over the course of the test are shown as the AUC. The difference in glucose tolerance between D100 compared with D270 and D100* mice was statistically significant (P<0.05).