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Wild-type CFTR regulates ADO-stimulated cAMP production. cAMP production was measured by ELISA in BHK cells and those stably transfected with either CFTR (BHKCFTR) or mutant CFTRs (D572N and ΔF508). Open bars denote vehicle; shaded bars denote 100 μM ADO. All n ≥ 12. *P < 0.05 vs. vehicle. †P < 0.05 vs. nonmutant CFTR with ADO.
