Figure 7.

Influence of intranasal PACAP38 administration on expression of Bcl-2 and RAGE in the brain of 6-mo-old APP[V717I]-transgenic mice. Animals were treated as described in Fig. 3. A) Quantification of Bcl-2 mRNA level by quantitative real-time RT-PCR (n=7 animals/group). B) Representative Western blots and quantitative analysis of Bcl-2 expression; 160 μg of mouse brain membrane proteins was analyzed (n=12 animals/group). C) Quantification of RAGE mRNA level by quantitative real-time RT-PCR (n=7 animals/group). Quantification of mRNA levels was performed as described in Fig. 3D. *P < 0.05, **P < 0.01, ***P < 0.001.