Table 2.
Dobutamine-stimulated hemodynamics
| Parameter | C57BL/6, n = 9 | δ-SG KO, n = 7 | γ-SG KO, n = 7 | mdx, n = 9 |
|---|---|---|---|---|
| Heart rate (bpm) | 631 ± 8 | 641 ± 19 | 611 ± 18 | 590 ± 8 |
| End-diastolic volume (μl) | 30.6 ± 2.0 | 27.1 ± 4.5 | 27.6 ± 4.9 | 30.0 ± 2.2 |
| End-systolic volume (μl) | 4.8 ± 0.7 | 6.7 ± 2.1 | 5.6 ± 2.0 | 12.6 ± 3.1* |
| Stroke volume (μl) | 29.8 ± 1.9 | 23.6 ± 3.4 | 24.7 ± 4.2 | 21.6 ± 1.2 |
| Cardiac output (ml/min) | 18.7 ± 1.1 | 15.1 ± 2.2 | 14.9 ± 2.4 | 12.7 ± 0.7* |
| End-diastolic pressure (mmHg) | 8.7 ± 0.4 | 7.5 ± 0.7 | 8.4 ± 0.9 | 12.3 ± 1.1* |
| Minimum pressure (mmHg) | 4.7 ± 0.6 | 4.9 ± 0.8 | 5.5 ± 0.7 | 9.9 ± 0.9* |
| Tau (ms) | 5.3 ± 0.1 | 5.1 ± 0.2 | 6.2 ± 0.3 | 7.4 ± 0.5* |
| End-systolic pressure (mmHg) | 127.5 ± 11.8 | 84.3 ± 3.8* | 80.8 ± 4.0* | 76.1 ± 5.3* |
| dP/dtmax (mmHg/s) | 15,764 ± 289 | 10,256 ± 978* | 9930 ± 1,066* | 7756 ± 915* |
| dP/dtmin (mmHg/s) | −10,168 ± 601 | −7785 ± 585* | −5637 ± 311* | −5066 ± 488* |
| Maximum filling rate (μl/s) | 1362 ± 125 | 1094 ± 171 | 1253 ± 254 | 991 ± 79 |
| Maximum emptying rate (μl/s) | −1650 ± 125 | −1403 ± 194 | −1676 ± 295 | −1444 ± 122 |
Data are expressed as means ± se.
*
P < 0.05 vs. control C57BL/6; 1-way ANOVA.