Table 2.
Association of GSTM1 and GSTT1 copy number with endometrial cancer risk by smoking status, postmenopausal hormone use and BMI in the pooled NHS and WHS data
| Never smokers |
Past smokers |
Current smokers |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | |
| GSTM1c | |||||||||
| null | 92 | 207 | 1.00 | 66 | 213 | 1.00 | 17 | 67 | 1.00 |
| carrier | 74 | 191 | 0.87 (0.59, 1.28) | 51 | 168 | 0.98 (0.63, 1.53) | 18 | 65 | 0.78 (0.31, 1.99) |
| Pinteractionb | 0.96 | ||||||||
| GSTT1c | |||||||||
| null | 21 | 74 | 1.00 | 19 | 84 | 1.00 | 5 | 24 | 1.00 |
| carrier | 144 | 322 | 1.69 (0.97, 2.94) | 95 | 303 | 1.31 (0.74, 2.34) | 29 | 103 | 2.08 (0.57, 7.54) |
| Pinteractionb | 0.92 | ||||||||
| Never PMH users |
Past PMH users |
Current PMH users |
|||||||
| Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | |
| GSTM1c | |||||||||
| null | 52 | 200 | 1.00 | 33 | 92 | 1.00 | 91 | 200 | 1.00 |
| carrier | 47 | 163 | 1.12 (0.69, 1.80) | 24 | 84 | 0.76 (0.39, 1.50) | 77 | 179 | 0.94 (0.64, 1.38) |
| Pinteractionb | 0.57 | ||||||||
| GSTT1c | |||||||||
| null | 18 | 77 | 1.00 | 4 | 37 | 1.00 | 20 | 70 | 1.00 |
| carrier | 78 | 285 | 1.03 (0.56, 1.90) | 52 | 137 | 3.35 (1.06, 10.6) | 147 | 304 | 1.75 (1.00, 3.09) |
| Pinteractionb | 0.14 | ||||||||
| BMI <25 |
25<BMI<30 |
BMI >30 |
|||||||
| Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | Cases | Controls | ORa (95% CI) | |
| GSTM1 | |||||||||
| null | 90 | 305 | 1.00 | 55 | 180 | 1.00 | 67 | 90 | 1.00 |
| carrier | 59 | 286 | 0.69 (0.47, 1.00) | 55 | 154 | 1.12 (0.72, 1.77) | 64 | 72 | 1.21 (0.74, 1.99) |
| Pinteractionb | 0.13 | ||||||||
| GSTT1 | |||||||||
| null | 20 | 121 | 1.00 | 21 | 69 | 1.00 | 20 | 32 | 1.00 |
| carrier | 125 | 461 | 1.60 (0.95, 2.71) | 88 | 264 | 1.18 (0.67, 2.10) | 109 | 129 | 1.21 (0.63, 2.31) |
| Pinteractionb | 0.63 | ||||||||
a
Unconditional logistic regression adjusted for matching factors and smoking at diagnosis (except in smoking analysis), age at menarche, age at first birth and parity, BMI at diagnosis (except in BMI analysis), PMH use at diagnosis (except in PMH analysis), menopausal status and age at menopause at diagnosis, ever oral contraceptive use
b
Likelihood ratio test of interaction with 2df
c
Analysis restricted to post-menopausal women