Figure 1: Schematic representing the advantages offered by Salmonella (SL) as a cancer therapeutic agent.

Green box represents how the conventional chemotherapeutic agent (blue pentagon) is unable to penetrate deep into the fast growing tumor. Blue box represents the engineered-Salmonella therapy. Salmonella offers several advantages like (i) tumor-specificity, (ii)self-replicating potential, (iii) ability to be genetically engineered with either (a) gene silencing (red box), or (b) tumor sensitizing (brown box) or (c) bacterial toxin/effectors producing methodologies (purple box), leading to tumor regression by caspase-3 mediated and other mechanisms, (iv) ability to migrate to distal regions of the tumor and (v) most importantly to induce gap-junction in tumors leading to immune activation against the tumor.