Table 2.
Data of the various substrates and variables measured during atrial natriuretic peptide (ANP) infusion
| Baseline | ANP infusion | P value | |
| ANP (ng/l) | |||
| Arterial | 97 ± 23 | 109 ± 27 | NS |
| Mixed venous | 86 ± 21 | 123 ± 33 | < 0.05 |
| Nitrate (μmol/l) | |||
| Arterial | 33 ± 8 | 28 ± 6 | NS |
| Mixed venous | 30 ± 6 | 31 ± 6 | NS |
| cGMP (nmol/l) | |||
| Arterial | 12 ± 4 | 16 ± 5 | NS |
| Mixed venous | 11 ± 4 | 15 ± 5 | < 0.01 |
| Cardiac index (l/min/m2) | 4.3 ± 0.4 | 4.2 ± 0.4 | 0.08 |
| MAP (mmHg) | 76 ± 3 | 78 ± 4 | NS |
| MPAP (mmHg) | 25.0 ± 1.9 | 25.1 ± 2.1 | NS |
| PAWP (mmHg) | 9.4 ± 1.2 | 10.0 ± 1.4 | NS |
| CVP (mmHg) | 8.1 ± 1.3 | 7.5 ± 1.2 | NS |
| PVRI (dyne s/cm5/m2) | 314 ± 36 | 305 ± 32 | NS |
| ITBVI (ml/m2) | 882 ± 39 | 925 ± 66 | NS |
| PBVI (ml/m2) | 184 ± 20 | 165 ± 27 | NS |
| RVEDVI (ml/m2) | 149 ± 8 | 150 ± 10 | NS |
| EVLWI (ml/kg) | 20.5 ± 1.7 | 21.3 ± 2.3 | NS |
| PaO2/FiO2 (kPa) | 18.0 ± 1.1 | 18.2 ± 1.5 | NS |
| A-a gradient (kPa) | 41.6 ± 3.8 | 41.8 ± 4.1 | NS |
| Qs/Qt (%) | 33.1 ± 2.0 | 34.7 ± 2.1 | NS |
NS, P > 0.2. The exact P values were established by a paired t test. The other variables were not normally distributed, and these were tested by the Wilcoxon signed-rank test. cGMP, Guanosine 3',5'-cyclic monophosphate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAWP, pulmonary artery wedge pressure; CVP, central venous pressure; PVRI, pulmonary vascular resistance index; ITBVI, intrathoracic blood volume index; PBVI, pulmonary blood volume index; RVEDVI, right ventricular end-diastolic volume index; EVLWI, extravascular lung water index; A-A, alveolar-arterial gradient.