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. 2011 Sep;90(3):591–597. doi: 10.1189/jlb.0910531

Figure 1. Systemic histamine levels increase rapidly after CLP.

Figure 1.

(A) WT mice were subjected to CLP (ligation at 50% of cecum; single puncture with 22-gauge needle), and serum histamine levels were measured at baseline (0 h) and 4, 12, and 24 h after CLP (n=4–5/group). (B) WT and Wsh mice were subjected to CLP, and histamine was measured in serum obtained 8 h later. Elevated histamine levels in WT mice indicate MC degranulation, as serum histamine was not elevated to the same degree in Wsh mice. (C) IL-6 increases after CLP. Error bars indicate sem; *P < 0.05; #P < 0.01.