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. 2011 Sep;90(3):591–597. doi: 10.1189/jlb.0910531

Figure 3. MC stabilization decreases systemic IL-6 levels after infection or inflammation.

Figure 3.

(A) IL-6 was measured in the serum of WT and Wsh mice at baseline, 8 h, and 24 h after infection. Wsh mice had higher serum IL-6 8 h after infection. (B) Cromolyn (Cr) leads to a nonstatistically significant decrease in IL-6, which is likely confounded by higher serum (C) and peritoneal (PL; D) bacterial loads. (E) Serum IL-6 levels were determined 90 min after LPS administration (3 mg/kg) in WT and cromolyn-treated WT mice. Mice treated with cromolyn had lower serum IL-6 levels, indicating that MCs contribute to the total amount of circulating IL-6 during systemic inflammation. Error bars indicate sem; *P < 0.05.