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Distribution of BRCA1 and BRCA2 mutations in primary and recurrent carcinomas by secondary mutation status. (A) Two of 48 BRCA1 mutation carriers with primary carcinomas had secondary mutations restoring BRCA1/2, compared with 0 of 16 BRCA2 mutation carriers (P = 1.00, Fisher's exact test). (B) Six of 31 BRCA1 mutation carriers with recurrent carcinomas had secondary mutations restoring BRCA1/2, compared with six of 13 BRCA2 mutation carriers (P = .13, Fisher's exact test).
