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. 2011 Jun 27;29(22):3037–3043. doi: 10.1200/JCO.2010.33.8038

Table 2.

Worst Treatment-Related Toxicity

Toxicity Grade by Treatment Phase Toxicity
Heme
GI
Fatigue
Neuropathy
Infusion Reaction
HFS
Acneiform Rash
Other
No. % No. % No. % No. % No. % No. % No. % No. %
Induction chemotherapy phase (n = 69)
    Grade 2 19 28 14 30 6 9 2 3 36 52 6 9
    Grade 3 7 10 7 10 2 3 1 1 2 3 2 3
    Grade 4 2 3
    Total grades 3 and 4 9 13 7 10 2 3 1 1 2 3 2 3
Chemoradiation phase (n = 60)
    Grade 2 1 2 14 23 8 13 3 5 22 37
    Total grades 3 and 4 1 2 2 3 1 2
Induction or chemoradiation phase (n = 69)
    Grade 2 22 32 18 26 6 9 2 3 3 5 37 54 6 9
    Grade 3 7 10 7 10 4 6 1 1 2 3 2 3
    Grade 4 2 3
    Total grades 3 and 4 9 13 7 10 4 6 1 1 2 3 2 3

Abbreviations: Heme, hematologic toxicity; HFS, hand-foot syndrome.