Table A2.
Multivariable-Adjusted Hazard Ratios for Development of SN2 From Time of SN1 and, for SMN2, From Time of SMN1 With Age As the Time Scale, Using Cause-Specific Hazards Model
| Characteristic | SN1 → SN2 |
SMN1 → SMN2 |
||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | |
| Age at diagnosis, years | ||||||
| < 10 | 1.00 | 1.00 | ||||
| ≥ 10 | 1.60 | 1.07 to 2.40 | .0222 | 2.17 | 0.52 to 9.13 | .2906 |
| Sex | ||||||
| Female | 0.96 | 0.76 to 1.22 | .7666 | 2.63 | 1.07 to 6.46 | .035 |
| Male | 1.00 | 1.00 | ||||
| Ethnicity | ||||||
| Other | 1.10 | 0.66 to 1.83 | .7256 | NA | ||
| Black non-Hispanic | 0.58 | 0.14 to 2.38 | .4531 | 1.37 | 0.16 to 11.54 | .7693 |
| Hispanic | 1.00 | 0.49 to 2.04 | .9978 | 1.88 | 0.53 to 6.75 | .3314 |
| White non-Hispanic | 1.00 | 1.00 | ||||
| First-degree relative with cancer | ||||||
| Yes | 1.14 | 0.89 to 1.47 | .2923 | 1.75 | 0.91 to 3.36 | .0924 |
| No | 1.00 | 1.00 | ||||
| Radiation exposure | ||||||
| Yes | 2.01 | 1.27 to 3.17 | .0028 | 0.41 | 0.20 to 0.85 | .0159 |
| No | 1.00 | 1.00 | ||||
| Age at SN1, years | ||||||
| < 30 | 1.00 | — | — | |||
| ≥ 30 | 1.82 | 1.19 to 2.78 | .0059 | — | ||
| Time from Primary to SN1 | ||||||
| Time from Primary to SN1 by 10 years | 1.46 | 1.07 to 1.98 | .0154 | — | — | |
| Education | ||||||
| < High school | 1.41 | 0.87 to 2.28 | .166 | 1.24 | 0.34 to 4.58 | .7416 |
| High school graduate | 0.93 | 0.64 to 1.34 | .6843 | 1.11 | 0.41 to 2.99 | .8426 |
| > High school | 1.00 | 1.00 | ||||
| Household income, $ per year | ||||||
| ≥ 20,000 | 1.39 | 0.96 to 2.01 | .0828 | 1.47 | 0.54 to 3.98 | .4538 |
| < 20,000 | 1.00 | 1.00 | ||||
| Smoking | ||||||
| Current | 0.87 | 0.60 to 1.25 | .4479 | 1.72 | 0.72 to 4.11 | .224 |
| Former | 0.92 | 0.66 to 1.29 | .6332 | 0.92 | 0.34 to 2.51 | .8701 |
| Never | 1.00 | 1.00 | ||||
| P53-associated SN1 | ||||||
| Yes | — | — | 1.46 | 0.76 to 2.80 | .2525 | |
| No | — | 1.00 | ||||
| Primary sarcoma | ||||||
| Yes | — | — | 1.10 | 0.52 to 2.34 | .8067 | |
| No | — | 1.00 | ||||
| Age at SMN1 | ||||||
| Age at SMN1 by 10 years | — | — | 1.09 | 0.30 to 3.93 | .9002 | |
| Time from primary to SMN1 | ||||||
| Time from primary to SMN1 by 10 years | — | — | 1.06 | 0.33 to 3.40 | .9178 | |
Abbrevations: NA, not applicable; SMN, subsequent malignant neoplasm; SN, subsequent neoplasm.