Fig 4.

Kaplan-Meier estimates for the combined data set of stage II (Cancer and Leukemia Group B [CALGB] 9581) and stage III (CALGB 89803) patients, representing comparisons between different marker-defined subsets. (A) Overall survival (OS; all-cause death) by mismatch repair (MMR) status (log-rank P = .029); (B) disease-free survival (DFS; documented recurrence of primary colon cancer or death as a result of any cause) by MMR status (log-rank P < .001); (C) OS by 18q status (log-rank P = .32); (D) DFS by 18q status (log-rank P = .39); (E) OS by 18q status with MMR deficiency (MMR-D) included among 18q intact (log-rank P = .021); (F) DFS by 18q status with MMR-D included among 18q intact (log-rank P = .002). 18qLOH, loss of heterozygosity at chromosomal location 18q; MMR-I, mismatch repair intact.