Table A3.
Multivariate Analysis of Prognostic Factors for DFS and OS
| Factor | DFS* |
OS† |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‡ | HR | 95% CI | P‡ | |
| Stage (II v III) | 0.56 | 0.47 to 0.66 | < .001 | 0.55 | 0.46 to 0.66 | < .001 |
| Sex (F v M) | 0.85 | 0.73 to 1.00 | .05 | 0.78 | 0.65 to 0.93 | .0055 |
| Age (continuous) | 1.017 | 1.01 to 1.02 | < .001 | 1.02 | 1.01 to 1.03 | < .001 |
| Performance status (0 v 1 v 2) | 1.39 | 1.18 to 1.63 | < .001 | 1.47 | 1.23 to 1.76 | < .001 |
| Tumor grade (I v II v III/IV) | 1.29 | 1.10 to 1.50 | .0014 | 1.38 | 1.16 to 1.64 | < .001 |
| No. of nodes sampled (continuous) | 0.98 | 0.97 to 0.99 | < .001 | 0.98 | 0.97 to 0.99 | .008 |
| Depth of tumor invasion (Tis/T1/T2 v T3 v T4a/T4b) | 1.66 | 1.35 to 2.04 | < .001 | 1.83 | 1.45 to 2.31 | < .001 |
| Extramural vascular invasion (yes v no) | 1.26 | 1.05 to 1.51 | .012 | 1.35 | 1.11 to 1.65 | .0025 |
| Mismatch repair deficiency (yes v no) | 0.76 | 0.62 to 0.94 | .012 | 0.75 | 0.59 to 0.94 | .016 |
Abbreviations: DFS, disease-free survival; OS, overall survival.
*
DFS: n = 1,813; 660 events.
†
OS: n = 1,813; 539 events.
‡
χ2.