Fig. 1.

a) Schematic showing targeting of cells from blood to inflamed endothelium expressing receptors that bind to ligands engineered on the cell surface. Two methods of engineering the homing ligand onto the cell surfaces, using covalent and noncovalent chemistry, are shown in b) and c), respectively. b) Stepwise process of attaching SLeX to MSCs using biotin-streptavidin linkers, and c) incorporation of palmitated protein G into the cell membrane and subsequent conjugation with an ICAM-1 antibody.(a) and b) reprinted with permission from27. ©ACS 2008. c) adapted with permission from28. ©Elsevier 2009).