Figure 4.

Role of NF-κB activation in the induction of proinflammatory mediators. The levels of induction of IL-6, IL-8, IL-1α, and ELAM-1 three days after H₂O₂ treatment were evaluated by realtime Q-PCR in the presence or absence of the NF-κB inhibitors Lact 10 μM and BAY 5 μM. The data show percentage changes in cultures treated with NF-κB inhibitors (Lact and BAY) and H₂O₂ compared to those treated with vehicle (DMSO) and H₂O₂. An asterisk means p<0.05; a double asterisk means p<0.01 (n=3–4).