Table 4. GWAIS and GWAS results on combined genotyped and imputed data.

SNP	BP			GWAIS in all NGRC subjects							GWAS In NGRC heavy coffee drinkers
				MAF	MAF	SNP		Interaction		2DF	MAF	MAF	OR	P
		Minor/Major Allele	Impute Info Score	Case	Control	OR (SE)	P	OR (SE)	P	P	Case	Control	(SE)
16-10105921	10105921	T/C	0.98	0.11	0.15	0.91 (0.11)	0.45	0.44 (0.09)	4×10−5	5×10−8	0.09	0.17	0.41 (0.07)	3×10−8
16-10103787	10103787	G/A	0.98	0.11	0.15	0.91 (0.11)	0.45	0.44 (0.09)	4×10−5	5×10−8	0.09	0.17	0.41 (0.07)	3×10−8
16-10102229	10102229	T/C	0.98	0.11	0.15	0.91 (0.11)	0.45	0.44 (0.09)	4×10−5	5×10−8	0.09	0.17	0.41 (0.07)	3×10−8
16-10102124	10102124	T/C	0.98	0.11	0.15	0.91 (0.11)	0.45	0.44 (0.09)	4×10−5	5×10−8	0.09	0.17	0.41 (0.07)	3×10−8
rs56275045	10108893	A/C	0.99	0.11	0.15	0.91 (0.11)	0.41	0.45 (0.09)	5×10−5	5×10−8	0.09	0.17	0.42 (0.07)	3×10−8
16-10109203	10109203	A/T	0.99	0.11	0.15	0.91 (0.11)	0.41	0.45 (0.09)	5×10−5	5×10−8	0.09	0.17	0.42 (0.07)	4×10−8
16-10110896	10110896	C/T	0.98	0.11	0.15	0.91 (0.11)	0.41	0.45 (0.09)	6×10−5	6×10−8	0.09	0.17	0.42 (0.07)	4×10−8
16-10101465	10101465	A/G	0.98	0.11	0.15	0.91 (0.11)	0.42	0.45 (0.09)	6×10−5	7×10−8	0.09	0.17	0.41 (0.07)	5×10−8
16-10092692	10092692	T/C	0.98	0.11	0.15	0.91 (0.11)	0.40	0.46 (0.09)	7×10−5	8×10−8	0.09	0.17	0.42 (0.07)	5×10−8
16-10093997	10093997	T/C	0.98	0.11	0.15	0.91 (0.11)	0.39	0.46 (0.09)	7×10−5	8×10−8	0.09	0.17	0.42 (0.07)	5×10−8
16-10094528	10094528	G/A	0.98	0.11	0.15	0.91 (0.11)	0.39	0.46 (0.09)	7×10−5	8×10−8	0.09	0.17	0.42 (0.07)	5×10−8
rs17671178	10094708	G/A	0.98	0.11	0.15	0.90 (0.11)	0.39	0.46 (0.09)	7×10−5	8×10−8	0.09	0.17	0.42 (0.07)	5×10−8

GRIN2A was the most significant area in both the GWAIS and the GWAS in heavy coffee users. This table shows results that achieved P≤5×10⁻⁸; for a complete list of all SNPs that achieved P<10⁻⁵ see Table S7.