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. 2011 Aug 18;7(8):e1002140. doi: 10.1371/journal.ppat.1002140

Figure 8. Model of CTCF-cohesin mediated chromatin conformation of KSHV latent episomes.

Figure 8

A) Linear schematic of KSHV latency control region and major latency transcripts. B) Depiction of 3C predicted loop between the CTCF-cohesin binding site and the 3′ end of the major latency transcript. C) Depiction of 3C predicted higher-order interaction between CTCF-cohesin site and the ORF50 promoter control region. Speculative model of how CTCF-cohesin may function to both insulate and coordinate latent and lytic viral gene expression.