Figure 6. Decreased neointima formation and lumen stenosis after femoral artery wire-denudation in CD40^−/− mice.

(A) Representative Elastic-stained sections (level 3) of femoral arteries 21d after injury in WT and CD40^−/− mice (left panel). Schematic diagram of femoral artery guidewire-induced injury and tissue microtomy (right panel). Arrows indicate the internal elastic lamina. Scale bars: 50 µm. (B) Intima was measured at the 7 cross-section levels (120-µm intervals), and their mean intimal area was calculated. Intima/media ratio (C) and lumen stenosis ratio (D) at each level as well as their mean ratios were determined. n = 10 mice per group. Data are expressed as mean ± SEM. * P<0.05 and ** P<0.01 versus corresponding WT.