Figure 2. Structures of cladoniamides and BE-54017 and its derivatives.

(A) Cladoniamides from Streptomyces uncialis and (B) BE-54017 and its derivatives. Derivatives of BE-54017 are labelled to be consistent with the labels used by Chang and Brady [13]; the compounds are currently unnamed. The major cladoniamide from Streptomyces uncialis is cladoniamide A [3]; the major metabolite from the heterologous expression of the BE-54017 gene cluster in Streptomyces albus is BE-54017 [13].