Table 1. Enzymes encoded by the cladoniamide gene cluster.

Enzyme	Sizea	Deduced function	BE-54017homologb	Sizea	% IDc	Rebeccamycin homologd	Sizea	% IDc
ClaH	513	Tryptophan 5-chlorinase	AbeH	515	74	RebH	530	40
ClaT	422	Na+/H+ antiporter	AbeT	412	55	RebT	473	14
ClaF	177	Flavin reductase	AbeF	160	60	RebF	170	46
ClaY	278	α/β hydrolase	AbeY	264	56	-	-	-
ClaO	519	l-tryptophan oxidase	AbeO	513	66	RebO	473	51
ClaC	561	Flavin-dependent oxygenase	AbeC	533	69	RebC	529	59
ClaP	420	Cytochrome P450	AbeP	392	64	RebP	397	54
ClaX1	553	Flavin-dependent oxygenase	AbeX1	533	71	-	-	-
ClaM1	243	N-Methyltransferase	AbeM1	231	73	-	-	-
ClaD	1090	Chromopyrrolic acid synthase	AbeD	1015	68	RebD	1013	53
ClaX2	421	Flavin-dependent oxygenase	AbeX2	407	73	-
ClaM3	344	O-methyltransferase	AbeM3	336	66	-
ClaR	981	Transcriptional regulator	AbeR	932	46	RebR	923	35

^ain amino acids.

^bfrom GenBank accession JF439215 [13].

^cpercent identity on the amino acid level as determined by pair-wise ClustalW alignment [46].

^dfrom GenBank accession AJ414559 [10].