Table 2.
Phenotypes of CD4+CD25+ cells induced by HCV variants
| Median (range) (%) | |||
|---|---|---|---|
| CD4+ cells | HCV- (n = 3) | HCV+ (n = 6) | p value* |
| Medium | |||
| CD25+ | 8.31 (6.0 - 11) | 23.4 (19 - 28) | 0.03 |
| TGFβ+ | 5.28 (3.5 - 9.0) | 56.0 (46 - 61) | 0.01 |
| IL-10+ | 3.22 (2.5 - 3.5) | 7.54 (6.0 - 17) | 0.04 |
| TGFβ+ IL-10+ | 0.67 (2.0 - 5.5) | 7.85 (5.0 - 14) | 0.04 |
| NS3358-375 | |||
| CD25+ | 10.1 (10 - 14) | 21.6 (18 - 27) | 0.02 |
| TGFβ+ | 5.04 (2.0 - 8.5) | 55.4 (37 - 59) | 0.01 |
| IL-10+ | 2.95 (2.6 - 3.2) | 6.51 (3.0 - 11) | 0.03 |
| TGFβ+ IL-10+ | 0.67 (0.5 - 2.5) | 7.85 (5.0 - 12) | 0.002 |
| VP1 | |||
| CD25+ | 10.2 (7.0 - 13) | 29.9 (21 - 48) | 0.01 |
| TGFβ+ | 6.18 (2.0 - 14) | 57.1 (42 - 61) | 0.06 |
| IL-10+ | 5.77 (3.5 - 7.5) | 6.23 (5.0 - 13) | 0.33 |
| TGFβ+ IL-10+ | 7.84 (2.0 - 6.5) | 8.65 (5.0 - 15) | 0.21 |
| VP2 | |||
| CD25+ | 8.60 (5.0 - 13) | 29.3 (23 - 51) | 0.02 |
| TGFβ+ | 7.04 (3.0 - 13) | 58.8 (44 - 67) | 0.04 |
| IL-10+ | 6.57 (6.0 - 8.5) | 7.73 (5.5 - 12) | 0.36 |
| TGFβ+ IL-10+ | 3.05 (2.5 - 7.0) | 9.36 (5.0 - 17) | 0.07 |
*: Wilcoxon non-parametric t-test
All subjects are positive for HLA-DRB1*15.