Fig. 3.

The alternative pathway to DHT synthesis drives CRPC progression. CRPC growth in the LAPC4 (Upper) and LNCaP (Lower) CRPC models have more robust growth in orchiectomized mice supplemented with AD versus T (0.25 mg sustained-release steroid pellets). Control mice underwent orchiectomy and no steroid supplementation. Time from injection of tumor cells to tumor volume ≥ 50 mm³ (Left) and tumor volume ≥ 300 mm³ (Right) is statistically significantly different for both models and both endpoints using a log rank test and a pairwise comparison of AD versus T cohorts.