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. 2011 Aug 1;108(33):E488–E497. doi: 10.1073/pnas.1100898108

Fig. 4.

Fig. 4.

Cytokine secretion profiles of tonsillar Th populations. (A and B) Cytokine secretion on interaction with B-cell subsets. The four Th populations were cultured with either naïve B cells (A; n = 6) or GC-B cells (B; n = 5), and the secretions of IL-10, IL-21, IL-17A, and IL-4 were analyzed on day 2. One-way ANOVA Bonferonni multiple comparison test. ***P < 0.001, **P < 0.01, and *P < 0.05. (C) CXCL13 secretion on interaction with naïve B cells (Upper; n = 4) or GC-B cells (Lower; n = 3). One-way ANOVA Bonferonni multiple comparison test. (D) Kinetics of IL21 and CXCL13 expression. The four Th populations were analyzed for the expression of IL21 and CXCL13 by real-time RT-PCR before and after stimulation with CD3/CD28 mAb-coated beads (n = 2–3). One-way ANOVA Bonferonni multiple comparison test for n = 3 and paired t test for n = 2.