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. 2011 Aug 1;108(33):E488–E497. doi: 10.1073/pnas.1100898108

Fig. 5.

Fig. 5.

Molecules associated with helper activity of tonsillar Th populations. (A) IL-21R/Fc chimera protein was added to the cultures of Th populations and the indicated B-cell subsets. Ig concentrations at day 8. A representative from four experiments. Paired t test. ***P < 0.001, **P < 0.01, and *P < 0.05. (B) ICOS mAb was added to the cultures of Th populations and the indicated B cells. Ig concentrations at day 8 (a representative from four experiments). Paired t test. (C) Cytokine secretion. CD40L mAb, ICOS mAb, or an isotype control was added to the cultures of Th populations and the indicated B cells. Cytokine concentrations at day 2 (a representative from three experiments).