Table 2.

Lamivudine pharmacokinetic parameters for infants studied at ages 4–7 days, 10–14 days and both groups combined. Data presented as medians (ranges). (bql=below quantitation limit of assay of 0.04 ug/ml).

	4–7 Days	10–14 Days	Combined
	(n=13)	(n=12)	(n=25)
t max (hours)	2.8 (1–4)	2.5 (1–4)	2.5 (1–4)
Cmax (ug/mL)	1.08 (0.38–2.01)	1.27 (0.38–2.17)	1.24 (0.38–2.17)
C12h (ug/mL)	0.31 (bql-0.74)	0.22 (bql -0.62)	0.23 (bql -0.74)
AUC0-12 (ug*hr/mL)	7.0 (2.9–15.6)	7.9 (2.7–14.0)	7.8 (2.7–15.6)
Cl/F (L/hr/kg)	0.27 (0.11–0.70)	0.27 (0.14–0.74)	0.27 (0.11–0.74)
t ½ (hours)	5.3 (3.3–10.5)	3.9 (3.1–6.3)*	4.7 (3.1–10.5)

^*p<0.05 compared to 4–7 Days