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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Jun 16;31(9):2063–2069. doi: 10.1161/ATVBAHA.111.225870

Figure 1.

Figure 1

Improved Gastric Bypass Surgery (IGBS) reduced T-lymphocyte infiltration and IFNγ expression in mesenteric adipose tissue (MAT) of diabetic mice. A, Immunohistochemical staining was performed in control (m Leprdb) and diabetic (Leprdb) mice treated with either sham surgery or IGBS. Leprdb mice were assessed 5, 10, 20, and 30 days post IGBS (P5, P10, P20, and P30), or 20 days after sham surgery. m Leprdb mice were assessed 20 days after either sham surgery or IGBS. The results show that CD3 positive T-lymphocyte infiltration in MAT was higher in Leprdb+Sham versus IGBS. Data shown are representative of 4 separate experiments. B, mRNA expression of CD3 increased in MAT of Leprdb+Sham. IGBS significantly reduced CD3 mRNA levels in MAT. The mRNA (C) and protein (D) expression of T-lymphocyte hallmark cytokine, IFNγ, increased in MAT of Leprdb+Sham. IGBS decreased the mRNA and protein expression of IFNγ. Data represent mean±SEM, n=4-12 mice. *P<0.05 compared with m Leprdb+Sham surgery; #P<0.05 compared with Leprdb+Sham surgery.