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. Author manuscript; available in PMC: 2012 Nov 18.
Published in final edited form as: J Proteomics. 2011 May 4;74(12):2632–2641. doi: 10.1016/j.jprot.2011.04.023

Figure 2. Prospective and retrospective approaches for identification of potential biomarkers.

Figure 2

A biomarker-forward, focused, target-associated prospective approach specifically address biomarkers to select patients for therapy. Alternatively, an agnostic, trial-backwards, retrospective approach would apply biased selection with biological validation of translational endpoints against patient outcome in targeted agents’ trials.