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. 2011 Jun 22;36(10):2097–2102. doi: 10.1038/npp.2011.100

Figure 2.

Figure 2

Impact of D2 block on plasticity induced by intermittent theta burst transcranial magnetic stimulation (iTBS) and continuous (cTBS). The time-course plots show the effect of 400 mg sulpiride (SULP) on TBS-induced neuroplasticity. Depicted are the baseline-standardized motor-evoked potential (MEP) amplitudes after plasticity induction by iTBS or cTBS under SULP or placebo (PLC) medication for up 60 min after the end of TBS. As shown by transcraninal magnetic stimulation (TMS)-elicited MEP amplitudes, under PLC medication, iTBS enhances, whereas cTBS diminishes cortical excitability significantly for up to 60 min after stimulation. Under SULP, the TBS-generated excitability shifts are abolished. Filled symbols indicate significant deviations of the post-TBS MEP amplitudes from baseline, asterisks indicate significant deviations of SULP vs PLC condition with regard to identical time points and TBS protocols (t-test, two-tailed, paired samples, p<0.05). The error bars show SEM.