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. 2011 Jun 8;36(10):2125–2138. doi: 10.1038/npp.2011.104

Figure 6.

Figure 6

Mean (±SEM) changes in EEG and EMG total powers (a–f) and selected cortical EEG waves (g–i) induced by i.v. NIC-PM (10 and 30 μg/kg, red curves) in freely moving rats. EEG total power is expressed in %, with 100%=basal value for 60-s pre-injection. EMG total power is expressed in ln(%), with the same 100% baseline determined for 60 s pre-injection. Changes in each individual wave power are shown in percents from EEG total power (=100%). Hatched vertical lines show the onset and offset of 15-s injection and hatched horizontal lines show basal values. n=number of averaged tests. An ANOVA with repeated measures revealed a significant effect of time on EEG and EMG total powers (for NIC-PM at 10 μg/kg: cortical EEG=F14, 1680=2.52, VTA filed potentials=2.16, EMG=1.51; for NIC-PM 30 μg/kg: F20, 2400=1.93, 1.77, 1.35; each p<0.001). The effect of time for NIC-PM at 10 μg/kg was significant with respect to δ (F14, 840=1.48, p<0.05), α (=2.68, p<0.01, g), and γ (=7.38, p<0.001, i) powers and insignificant with respect to θ (=0.96) and β (=1.29) waves. Values significantly different from baseline are shown as filled symbols. Superimposed blue and black curves indicate changes induced by NIC and saline, respectively.