Table 1. Mean Changes in Rapid and Long-Term Components of EEG and EMG Responses Induced by Drugs Used in This Study.
| Parameters | Rapid changes (5–30 s) | Long-term changes (30–300 s) |
|---|---|---|
| EEG, % | ||
| Cortex | ||
| Saline | 50.59±5.00 | 86.19±3.17 |
| NIC 10 | 38.48±2.30* | 53.35±5.11*** |
| NIC 30 | 33.09±1.68*** | 36.91±2.78*** |
| NIC 30+urethane | 72.23±3.29**,††† | 53.11±6.11*** |
| NIC 30+HEXA | 41.89±3.21† | 62.92±6.65**,††† |
| NIC-PM 10 | 32.69±2.03** | 73.53±5.04*,††† |
| NIC-PM 30 | 44.41±3.25†† | 72.25±4.10*,††† |
| VTA | ||
| Saline | 45.65±3.59 | 78.54±2.99 |
| NIC 10 | 31.85±1.37** | 47.35±4.98*** |
| NIC 30 | 26.22±1.64*** | 29.27±2.58*** |
| NIC 30+urethane | 77.47±7.85**,††† | 42.99±6.50*** |
| NIC 30+HEXA | 43.71±4.96††† | 61.22±7.46*,††† |
| NIC-PM 10 | 27.33±1.34** | 67.44±6.77††† |
| NIC-PM 30 | 35.53±1.83* | 64.96±5.39††† |
| EMG, ln(%) | ||
| Saline | 5.83±0.19 | 4.81±0.18 |
| NIC 10 | 6.67±0.27** | 6.28±0.43** |
| NIC 30 | 8.63±0.42*** | 8.07±0.29*** |
| NIC 30+urethane | 4.66±0.14***,††† | 4.73±0.09††† |
| NIC 30+HEXA | 7.29±0.38***,† | 6.18±0.41**,††† |
| NIC-PM 10 | 6.38±0.17*,††† | 5.15±0.43††† |
| NIC-PM 30 | 6.95±0.19***,††† | 5.44±0.54††† |
Each value represents a mean value of total power (±SEM) calculated for distinguished time intervals. Asterisks define statistical significance of differences vs saline (*p<0.05, **p<0.01, and ***p<0.001) and †define statistical differences vs NIC 30 μg/kg (†p<0.05; ††p<0.01, and †††p<0.001; Student's t-test). The numbers of tests in each group are shown in figures.