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. 2011 Jun 15;36(10):2054–2061. doi: 10.1038/npp.2011.96

Figure 5.

Figure 5

Acute treatment with olanzapine (1.5 mg/kg i.p.) reverses PCP-induced loss of asymmetric spine synapses in layer II/III of PFC. One-way ANOVA revealed a significant effect of treatment group (F(3, 14)=24.8, p<0.0001). Scheffe's post-hoc test showed that PCP-treated rats given acute vehicle (PCP-VEH) had a significant decrease in number asymmetric synapses in PFC compared with saline-treated rats given acute vehicle administration (SAL-VEH) indicated by an asterisk; this effect was reversed in PCP-treated rats given acute olanzapine (PCP-OLZ). The number of asymmetric synapses in saline-treated rats given acute olanzapine (SAL-OLZ) was not significantly different from the number in saline-treated rats given acute vehicle (SAL-VEH). There were four rats in each group, except SAL-OLZ, which contained three rats.