Table 1.
Clinical information of the 9 previously reported cases and of the authors' patient with renal wasting hypophosphatemia associated with SCC
| Patient number | Age (years) /Gender /Ethnicity | History of smoking | Symptoms /Duration before the onset of hypophosphatemia | Paraneoplastic syndrome(s) | Site of the primary tumor / Site(s) of the tumor metastasis /Treatment | Bone biopsy | Cause of death / time until death after the onset of hypophosphatemia |
| 2 | 56 / Female /African-American | NA | Weakness, diffuse body aches and nausea. Temporal wasting/1 month | Fanconi +/− SIADH | Pulmonary /Bone marrow /Chemotherapy | NA | Gram negative septicemia during pancytopenia /20 months |
| 3 | 69 / Male | NA | Dysuria, hematuria, urinary frequency, and nocturia / 1 month | Hypophosphatemia | Urinary bladder (Kultschitzky-type cell) / No evidence / Surgery | Not Done | Loss to F/U 15 mo from the onset of hypophosphatemia |
| 4 | 57 / Male | Yes | Nontraumatic tarsal pain of both feet. Hemoptysis 2 times /1 month | Phosphate diabetes | Pulmonary /Tarsal and iliac bones /Chemotherapy and radioherapy | Strongly suggestive of osteomalacia | NA / 10 months |
| 5 | 37 / Male | NA | Mild dysphagia, weight-loss, hemoptyses, and pain affecting the lumbar spine, buttocks, and thighs | Renal phosphate wasting and SIADH | Pulmonary / Not available / Chemotherapy | NA | NA / 15 months |
| 6 | 57 / Male | NA | Nausea, polyuria, weakness / 1 month (SIADH started first) | Oncogenic osteomalacia and SIADH | Pulmonary / Liver, thoracolumbar spine /Pneumonectomy | Osteomalacia | NA / 3 months |
| Authors' Patient | 60 / Male /Caucasian | 80 packs per year | Nausea, vomiting, generalized malaise and weakness / 2 months (SIADH started first) | Renal phosphate wasting and SIADH | Pulmonary / Liver /Chemotherapy | Not Done | Pancytopenia, septic shock with multi-organ failure / 1.5 months |
| 7 | 72 / Male | 1 pack per day, many years | Chest pain and weight-loss / Same | Renal phosphate wasting and SIADH | Pulmonary / No further work-up due to the patient deteriorated rapidly / No | No | NA/ Same period |
| 8 | 58 / Female | NA | Dysphagia, epgastric pain, weight-loss (1 stone) / 12 months | Oncogenic osteomalacia and Cushing's syndrome | Trachea /Lymph nodes, liver, pancreas, adrenal glands, vertebrae /Esophagectomy | Osteomalacia | NA / 1 month |
| 9 | 46 / Male | NA | Back pain, cervical adenopathy / Same | Renal phosphate wasting, SIADH and Cushing's syndrome | Extrapulmonary / Bone /Chemotherapy | Not Done | NA / 10 months |
NA = Not available