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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2011 Aug 1;4(4):577–585. doi: 10.1161/CIRCEP.110.957662

Figure 2. Pathogenic mutations and risk-conferring polymorphisms in KATP channel genes associated with human cardiac disorders.

Figure 2

Topology of Kir6.2/Kir6.1 and SUR2A (with nucleotide binding domain NBD1/NBD2 and transmembrane domains TMD0-TMD1-TMD2) subunits, with mapped locations of variant sites underlying KATP channelopathies.