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. 2011 Jul 14;17(26):3117–3125. doi: 10.3748/wjg.v17.i26.3117

Figure 3.

Figure 3

Interferon γ suppresses ghrelin expression in the gastric fundus and ghrelin concentrations in plasma independently of loss of ghrelin-producing cells. Mice infused with interferon γ (IFNγ) as compared to saline infused mice (n = 6 in each group). IFNγ was infused at low dose (LD) = 8 μg/kg per hour for 7 d or high dose (HD) = 24 μg/kg per hour for 7 d. Low (A) and high (B) dose IFNγ infusion decreases the expression of ghrelin mRNA to a similar degree. HD IFNγ represses ghrelin concentrations in plasma gradually over time (C). The density of fundic ghrelin cells is not altered by IFNγ infusion (D). aP < 0.05.