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. 2011 May 28;18(4):201–210. doi: 10.1093/dnares/dsr008

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© The Author 2011. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Summary of SNP array results for donor and recipient inside and outside MHC. Analysis of Affymetrix microarray HGW SNP 6.0 data for SNP density and signal intensities. (A) The slope of the graph represents the cumulative number of variant SNPs (x = number of SNPs; y = number of variant SNPs). Inset MHC region (Chr.6: 29 000 000–34 999 000 only) and with unrelated not HLA matched control sample (inset blue). (B) Correlation of signal intensities for concordant and variant SNP's inside and outside the MHC region. Taken together, showing that HLA matching in contrast to an unrelated and HLA unmatched control sample significantly reduces the variant SNP density in MHC regions (R = 0.892 versus R = 0.704; z = 6.76) and not in non-MHC regions (R = 0.801 versus R = 0.740; z = −34.53).